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Journal of Case Reports
Is There a Role for Bone Marrow Biopsy In The Diagnosis of Masked Polycythemia Vera with Splanchnic Vein Thrombosis?
Maria Cristina Scamuffa, Roberto Latagliata, Luisa Bizzoni, Maria Lucia De Luca, Federica Falco, Sofia Chiatamone Ranieri, Massimo Breccia, Robin Foà, Marco Vignetti, Stefania Trasarti
Division of Hematology, Department of Precision and Translational Medicine, Sapienza University, Rome, Italy.
Corresponding Author:
Dr Stefania Trasarti 
Email: trasarti@bce.uniroma1.it
Received: 12-DEC-2019 Accepted: 14-MAR-2020 Published Online: 25-MAR-2020
DOI: http://dx.doi.org/10.17659/01.2020.0016
Background: Philadelphia-negative chronic myeloproliferative neoplasms are the most common underlying prothrombotic disorders found in patients with splanchnic vein thromboses. A sizeable proportion of patients with splanchnic vein thromboses carry a Jak2-V617F mutation, despite the absence of overt signs of myeloproliferative neoplasm. Case Report: We report a case of a 46-year-old male presenting with splenomegaly and anemia. Subsequently, due to the appearance of abdominal pain, thrombosis of the portal vein, intra-hepatic portal branches and splenic vein were found. The simultaneous presence of splenomegaly and splanchnic vein thromboses prompted a search for an underlying myeloproliferative neoplasm and a diagnosis of splanchnic vein thromboses from a “masked polycythemia vera” was posed. Conclusion: This uncommon case highlights the importance of an early myeloproliferative neoplasms screening when a splanchnic vein thromboses is diagnosed.
Keywords : Myeloproliferative Disorders, Polycythemia Vera, Portal Vein, Splenic Vein, Splenomegaly, Thrombosis.
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