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Journal of Case Reports
Rituximab Induced Increased Intraocular Pressure in Recalcitrant Scleritis
Gayatree Mohanty, Shovna Dash 
Department of Ophthalmology, Kalinga Institute of Medical Sciences & Pradyumna Bal Memorial Hospital, Bhubaneswar, Odisha, India.
Corresponding Author:
Dr Shovna Dash
Email: friend.shovna@gmail.com
Received: 26-AUG-2019 Accepted: 11-DEC-2019 Published Online: 15-JAN-2020
DOI: http://dx.doi.org/10.17659/01.2020.0003
Background: We  report  a  rare  adverse  effect  of  rituximab,  a  monoclonal  antibody  against  CD20  antigen  targeted  lymphocytes,  which  has  been  recently  used  in  the  potentially  sight  threatening  recalcitrant  non-infectious  scleritis  with  promising  results.  It  has  been  documented  to  have  reduced  the  need  of corticosteroids  with  minimal  adverse effects. Case Report: A  25  year  old  female  with  recalcitrant  scleritis  due  to  granulomatosis  with  polyangiitis,  not  responding  to  systemic  cyclosporine  and  steroid,  presented  with  increased  intraocular  pressure  following  each  of  the  three  cycles  of  rituximab  but  complete  resolution  of  scleritis.  Conclusion: Hence,  as  the  utility  of  rituximab  expands,  the  awareness  of   rheumatologists  and  physicians  regarding  its  ocular  adverse  effects  is  crucial.
Keywords : Cyclosporine, Intraocular Pressure, Rituximab, Scleritis.
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