Background: Oral cancers are the one of the most common causes of non-healing ulcers in the oral cavity and usually diagnosed easily on clinical examination due to their characteristic appearance. However, we present a case of oral localized histoplasmosis which perfectly masqueraded clinic-radiologically as an oral cancer. Case Report: The patient, known tobacco chewer, presented with chief complaints of non-healing ulcer over the left buccal mucosa and the right upper alveolus. Clinical appearance was that of an oral cancer with everted edges, infiltrative growth and surrounding induration. MRI was suggestive of hyperintense thickening. On biopsy of the lesion, dysplasia was not seen. Multinucleated giant cell with large PAS positive inclusion bodies were present suggestive of histoplasmosis. Individual responded to oral itraconazole. Conclusion: No oral cancer should be treated without biopsy of the lesion to rule out cancer mimics like histoplasmosis. Oral localized histoplasmosis in immunocompetent is extremely rare and is treatable with oral azole therapy.