Background: Myeloid sarcoma (MS) may occur de novo, precede or coincide with acute myeloid leukemia (AML) but its presentation as the initial manifestation is rare. Case Report: We present a series of six cases of myeloid sarcoma in an age group ranging from 15 to 62 years, involving paraspinal area, lymph node, ileum and appendix. Three cases had a prior diagnosis of AML and in the rest, a diagnosis of myeloid sarcoma preceded further investigations which did not reveal any other site of involvement. Conclusion: The diagnosis of myeloid sarcoma is important especially in patients who do not have associated hematologic abnormalities at presentation. Immunohistochemistry is an invaluable tool that assists in arriving at a correct diagnosis.