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Journal of Case Reports
Primary Mediastinal Germ Cell Tumors
Caroline E. Lippe, Troy Moritz
General Surgery Program, UPMC Pinnacle Community Osteopathic, 4300 Londonderry Road, Harrisburg, PA 17109, United States.

Corresponding Author:
Dr. Caroline E. Lippe
Email: caroline.e.lippe@gmail.com
Received: 17-JUL-2020 Accepted: 2-OCT-2020 Published Online: 20-DEC-2020
DOI: http://dx.doi.org/10.17659/01.2020.0069
Background: Primary malignant mediastinal germ cell tumors (PMMGCT) are exceedingly rare, accounting for 1-2% of germ cell tumors. The objective of this case report is to highlight the severity and unique characteristics of this tumor. Case Report: A young, active 33 year old male presented to a community emergency department with flu-like symptoms and hemoptysis continuously for one month. Work-up noted a large anterior mediastinal mass with erosion into the sternum. Biopsy revealed a non-seminomatous germ cell tumor, with primary malignant origin in the mediastinum. Chemotherapy was initiated, which the patient has tolerated well during his first few rounds of treatment. Conclusion: PMMGCTs are rare and aggressive tumors with variable response to chemotherapy. Extensive surgery has been offered for those with resistant factors, with more complications. 
Keywords : Biopsy, Germ Cell and Embryonal Neoplasms, Mediastinal Neoplasms, Nonseminomatous germ cell tumor, Neoplasms.
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