Background: The most frequent manifestations of COVID-19 occur due to involvement of lung, the SARS-CoV-2 virus may also lead to multi-system involvement including the liver damage. Case Report: We present a patient who presented with fever, multiple episodes of vomiting followed by altered mentation with deranged liver biochemistries attributable to COVID-19 infection. During hospital stay, patient was treated for COVID-19 and subsequently showed clinical improvement as well as improvement in lab parameters. Conclusion: This case report paves the way for further studies to determine the various mechanisms of liver involvement as well as the frequency of acute liver failure in COVID-19 and to help in better understanding of this disease.