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Journal of Case Reports
Successful Hematopoietic Stem Cell Transplantation in AML and Hepatosplenic Candidiasis: Case Report and Review of Literature
Haiyan Zhang
Department of General Practice, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong Province, People’s Republic of China.
Corresponding Author:
Dr Haiyan Zhang
Email: 596047716@qq.com
Received: 21-JUL-2020 Accepted: 04-JAN-2021 Published Online: 05-MAR-2021
DOI: http://dx.doi.org/10.17659/01.2021.0013
Background: Hepatosplenic fungal infection in patients with acute leukemia is a rare disease. Case Report: We report a 33-year-old female with acute myeloid leukemia (AML) who developed probable hepatosplenic fungal infection after induction chemotherapy, underwent hematopoietic stem cell transplantation (HSCT) from matched sibling brother successfully. The patient received anti-fungal treatment for seven months and lesions tended to stabilize before transplantation. She was also treated with voriconazole and caspofungin throughout transplantation. Repeat abdominal MRI post-transplant revealed obvious regression of hepatic and splenic lesions. Eventually, she was discharged with full recovery of cell count. Conclusion: Complete imaging resolution of lesions is not a prerequisite for HSCT if the infection can be controlled with antifungal therapy.
Keywords : Acute Myeloid Leukemia, Antifungal Agents, Caspofungin, Hematopoietic Stem Cell Transplantation, Mycoses, Voriconazole.
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