Background: Junctional ectopic tachycardia (JET) is one of the rare supraventricular tachycardia seen in infancy and childhood. Case Report: We report a rare case of hypoxia and polyionotrope induced JET in a 11-year-old child with Ewing sarcoma admitted with septic shock. Conclusion: Ionotropes can accelerate any myofibre but this is a rare case where polyionotropes accelerated the atrioventricular junction (AV junction) resulting in incessant JET.