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Journal of Case Reports
Fatal Mycoplasma Associated Cold Agglutinin-Mediated Acute Autoimmune Hemolytic Anemia
Maryam Alasfour, Maram Alenzi
Department of Internal Medicine, University of Miami, Miami, FL 33136, United States.
Corresponding Author:
Dr. Maryam Alasfour
Email: alasfour.mariam@gmail.com
Received: 15-SEP-2022 Accepted: 13-FEB-2023 Published Online: 15-APR-2023
DOI: http://dx.doi.org/10.17659/01.2023.0010
Background: Autoimmune hemolytic anemia (AIHA) is a known complication of various infections, the link between Mycoplasma infection and AIHA is relatively rare. This case emphasizes the importance of considering Mycoplasma as a potential trigger for AIHA, especially in patients presenting with progressive dyspnea, symptomatic anemia, and positive cold agglutinin test results. Case Report: A 72-year-old man was admitted to the hospital due to progressive dyspnea and symptomatic anemia. The patient had a history of mild anemia, indicating mild hemolysis, as evidenced by low haptoglobin and mildly elevated LDH levels on prior laboratory tests. Upon investigation, the patient's Coombs test revealed a positive result for anti-C3b/d, indicating the presence of cold agglutinin-mediated autoimmune hemolytic anemia. Additionally, Mycoplasma serology showed positive IgG results, confirming the presence of Mycoplasma infection-associated cold agglutinin syndrome (CAS). Conclusion: Early recognition and prompt initiation of targeted therapy are crucial to prevent disease progression and optimize patient outcomes in this rare and potentially life-threatening condition. Further research and awareness are warranted to improve the understanding and management of Mycoplasma-associated AIHA.
Keywords : Anemia, Cold Agglutinins, Dyspnea, Infections, Serology.
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