Background: Colonic lipomas are rare benign neoplasms within the gastrointestinal tract. They are often asymptomatic but can cause abdominal pain and other symptoms when they exceed 2 cm. Diagnosis involves imaging and colonoscopy, while surgical excision is recommended for symptomatic cases. Case Report: A 48-year-old female patient with a medical history of hypothyroidism and hypertension presented with colicky abdominal pain, nausea, and vomiting. Imaging revealed a large lipoma in the transverse colon, confirmed by colonoscopy. Surgical excision was performed, resulting in symptom resolution. Conclusion: Awareness of colonic lipomas and their potential for symptomatic presentation and role of imaging techniques is important for prompt diagnosis and appropriate management.