About the Journal | Editorial Board | Instructions to Contributors | Submission & Review | Advertise with Us | Subscribe to E- Alerts
Sitemap | Feedback
Advanced search
Journal of Case Reports
Plasma Exchange as Rescue Therapy for Patient with Poorly Responsive Guillain-Barre syndrome
Dawlat Sany1, Anandi Damodaran2, Devdutt Kotekar2
1Consultant Internal Medicine and Nephrology, Kalba Hospital, Sharjah, EHS. 2Consultant Neurologist, Kuwait Hospital, Sharjah, EHS, United Arab Emirates.
Corresponding Author:
Dr. Dawlat Hussein Sany
Email: dawlat.hussein@ehs.gov.ae
Received: 18-APR-2023 Accepted: 23-JUN-2023 Published Online: 25-JUL-2023
DOI: http://dx.doi.org/10.17659/01.2023.0020
Background: Intravenous immunoglobulin (IVIg) has traditionally served as the primary treatment for Guillain-Barré syndrome (GBS), reserving plasmapheresis for severe cases or as an adjunctive therapy with uncertain outcomes. Currently, there is no robust recommendation supporting the utility of therapeutic plasma exchange (TPE) following IVIg treatment failure. Case Report: In this report, we present a case of severe GBS accompanied by respiratory failure necessitating mechanical ventilation. Nerve conduction studies and electromyography (EMG) findings indicated a profound hyperacute motor sensory axonal neuropathy phenotype of GBS. Despite an initial course of IVIg at a dosage of 0.4 g/kg administered over five consecutive days, the patient exhibited no improvement. However, a notable turnaround in the patient's condition was observed following TPE. Conclusion: This case report underscores the potential benefit of TPE as a viable treatment option for select patients who fail to respond to immunoglobulin therapy, shedding light on its effectiveness in such challenging cases of GBS.
Keywords : Guillain-Barre Syndrome, Intravenous immunoglobulins, Plasmapheresis, Respiratory Failure, Sensory Neuropathy.
Article Options
Search PubMed for
Search Google Scholar for
Article Statistics
Bookmark and Share