Background: Lophomonas, a protozoa gaining recognition as a pathogen, has drawn increased attention owing to its link with respiratory tract infections. Typically residing in the hind-gut of cockroaches, Lophomonas has been identified as a causative agent impacting both upper and lower respiratory tracts in humans. This case report presents an unusual instance of bronchopulmonary lophomoniasis in a patient from Central India. Case Report: A 44-year-old man, who had previously contracted COVID-19, visited the Pulmonary Medicine outpatient department (OPD) with enduring respiratory symptoms. Despite undergoing various rounds of both injectable and oral antibiotics, there was no improvement in the patient's condition. Radiological examination revealed interstitial haziness and consolidation in the left mid and lower zones, accompanied by mild cardiomegaly on chest X-ray. Broncho-alveolar lavage (BAL) fluid analysis through wet mount examination, Giemsa, and Trichrome stain unveiled the presence of Lophomonas blattarum. Conclusion: This unique case illuminates the need for heightened awareness among healthcare professionals regarding the potential involvement of uncommon pathogens like Lophomonas in respiratory illnesses. The successful diagnosis through microscopic examination demonstrates the pivotal role of such techniques in guiding appropriate and targeted treatment.