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Journal of Case Reports
Prostate Specific Membrane Antigen Avid Thyroid Cancer in Patients with Prostate Cancer: A Report of Two Cases
Saranya Sasikala1, Anand Narayan Chinnachamy1, Arumugam Rajkumar2, Arulraj Pitchamuthu3
Departments of Radiation Oncology1, Medical Oncology2 and Surgical Oncology3, Valavadi Narayanasamy Cancer Center, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore 641037, India.
Corresponding Author:
Dr. Saranya Sasikala
Email: drsaranyasasikala@gmail.com
Received: 10-MAY-2023 Accepted: 14-OCT-2023 Published Online: 15-NOV-2023
DOI: http://dx.doi.org/10.17659/01.2023.0029
Background: Ga-68 labelled Prostate specific membrane antigen-Positron emission tomography (PSMA-PET) is widely used in staging of intermediate and high-risk prostate cancer or restaging after biochemical recurrence. Despite the term “prostate specific”, incidental uptake with Ga-68 PSMA-PET in benign and non-prostatic malignancy has been reported. Case Report: Here we present two cases of carcinoma prostate with PSMA-PET avid lesions in thyroid, requiring further evaluations due to its non-specificity and on evaluation found to be a synchronous double malignancy of prostate and carcinoma thyroid. Conclusion: PSMA-PET, though has high sensitivity and specificity in staging for prostate cancer, can be taken up by multiple other malignancies and non-malignant conditions. If clinical picture warrants, additional confirmatory investigations are required, might change the staging and the treatment. 
Keywords : Biopsy, Lung, Prostate, Prostate Specific Antigen, Staging, Thyroid.
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