Background: Ga-68 labelled Prostate specific membrane antigen-Positron emission tomography (PSMA-PET) is widely used in staging of intermediate and high-risk prostate cancer or restaging after biochemical recurrence. Despite the term “prostate specific”, incidental uptake with Ga-68 PSMA-PET in benign and non-prostatic malignancy has been reported. Case Report: Here we present two cases of carcinoma prostate with PSMA-PET avid lesions in thyroid, requiring further evaluations due to its non-specificity and on evaluation found to be a synchronous double malignancy of prostate and carcinoma thyroid. Conclusion: PSMA-PET, though has high sensitivity and specificity in staging for prostate cancer, can be taken up by multiple other malignancies and non-malignant conditions. If clinical picture warrants, additional confirmatory investigations are required, might change the staging and the treatment.