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Journal of Case Reports
Ectopic Cushing Syndrome Secondary to Metastatic Small Cell Carcinoma of Unknown Primary: A Multidisciplinary Approach
Colin Pierce1, Niyoti Reddy2, Joseph Rencic1, Umit Tapan3, Ivania M. Rizo2
1Department of Medicine, Section of Internal Medicine, Boston University Medical Center; 2Division of Endocrinology, Diabetes, Nutrition, and Weight Management, Section of Internal Medicine, Boston University Medical Center; 3Division of Oncology, Section of Internal Medicine, Boston University Medical Center, Boston, MA 02118.
Corresponding Author:
Dr Ivania M. Rizo
Email: Ivania.rizo@bmc.org
Received: 24-AUG-2022 Accepted: 30-OCT-2023 Published Online: 05-JAN-2024
DOI: http://dx.doi.org/10.17659/01.2024.0001
Background: Small cell lung cancer (SCLC) is a neuroendocrine tumor with the possibility to produce various peptides or hormones that can lead to paraneoplastic syndromes, such as ectopic ACTH secretion (EAS). The diagnosis of EAS is challenging and requires a multidisciplinary approach. Case Report: We report a case of a 64-year-old man who presented severe hypokalemia, metabolic alkalosis, worsening hyperglycemia and hypertension, found to have EAS secondary to metastatic small cell carcinoma of unknown primary. Conclusion: We review therapeutic options, including chemo-immunotherapy as part of the treatment regimen, for EAS.
Keywords : Adrenocorticotropic Hormone, Cushing Syndrome, Neuroendocrine Tumors, Small Cell Carcinoma.
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