Background: Sleep apnea syndrome (SAS) is a common sleep disorder characterized by recurrent episodes of upper airway obstruction during sleep, leading to disrupted sleep patterns and oxygen desaturation. SAS can have significant implications for cardiovascular health, with hypertension being a common co-morbidity. Despite its prevalence and associated risks, SAS often remains undiagnosed and untreated for many years, contributing to worsening cardiovascular outcomes. Case Report: This case report presents the clinical course of a patient initially diagnosed with severe SAS with an Apnea-Hypopnea Index (AHI) of 34 at the age of 30, the patient remained untreated for approximately two decades. Following a recent medical checkup in 2022, the patient was diagnosed with hypertension and referred to the hospital. Despite oral administration of antihypertensive drugs for less than a year, no significant improvement in blood pressure was observed. Due to persistent symptoms such as daytime sleepiness and early morning headaches, along with a history of SAS, Continuous Positive Airway Pressure (CPAP) therapy was initiated. Conclusion: Detailed blood pressure recordings over the preceding months demonstrated a statistically significant improvement, highlighting the efficacy of CPAP therapy in managing refractory hypertension in patients with SAS. Enhanced compliance with CPAP therapy can be facilitated through regular blood pressure monitoring, ultimately improving clinical outcomes and quality of life in this patient population.