Adenocarcinoma of the duodenum is a remarkably rare tumor. Its vague and non-specific clinical presentation often misleads clinicians and patients to suspect other more benign differential diagnoses. Improved endoscopy and imaging have enabled more of these cases to be diagnosed. Definitive surgery is the only means of potential cure, with the prognosis seems to be better for node-negative patients. We present a 55-year-old female who underwent a Whipple’s operation for this uncommon disease.