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Pulmonary Tumor Thrombotic Microangiopathy by Lung Adenocarcinoma
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Ikutarou Furuno1,2, Seiya Tanaka1, Hiromichi Ueno2, Hisaharu Ooe2, Yugo Yoshida3, Takashi Harada1, Yukikazu Awaya3, Hiromi Tasaki1, Tatsuro Shimokama4
From the Department of Cardiology1and Respirology3, Kitakyushu Municipal Yahata Hospital, 4-18-1 Nishihon-machi, Yahatahigashi-ku, Kitakyushu, Japan; The Second Department of Internal Medicine2, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; and Department of Pathology4, Steel Memorial Yawata Hospital, Kitakyushu, Japan. |
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Corresponding Author:
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Dr. Seiya Tanaka
Email: seiya-t@med.uoeh-u.ac.jp |
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Received:
11 JUNE 2013 |
Accepted:
21-JUN-2013 |
Published Online:
25-JUL-2013 |
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Abstract
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Pulmonary tumor thrombotic microangiopathy, which was established as a disease entity by von Herbay et al, is an uncommon cancer-related complication. The most common disease associated with pulmonary tumor thrombotic microangiopathy is poorly differentiated adenocarcinoma of the stomach, and cancers other than gastric cancers are very rare. We present a case of pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma which was found in a 61-year-old Japanese woman. She was taken suffering from general fatigue without any history of cancers. Two-days after admission she suddenly complained of dyspnea and succumbed to pulmonary hypertension. Postmortem autopsy revealed that lung adenocarcinoma with multiple liver metastasis and intimal proliferation of pulmonary small arteries with or without tumor emboli, which were characteristics of pulmonary tumor thrombotic microangiopathy.
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Keywords :
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Adenocarcinoma, Pulmonary Hypertension, Lung Neoplasms, Liver, Dypnea.
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