Cribriform lesions of the prostate can be of difficult histological interpretation and have diagnostic pitfalls. We discuss the case of a patient presenting with urinary obstruction symptoms for which he underwent transurethral prostatic resection. Histology of the prostate chips revealed a cribriform lesion which posed a challenging differential diagnosis between benign hyperplastic lesion, prostatic intraepithelial neoplasia and possibly a malignant lesion. The careful examination of the cytology of the lesion, the use of immunohistochemistry and peer review of the case helped excluding cribriform prostatic carcinoma and cribriform intraepithelial neoplasia. We diagnosed this case as clear cell cribriform hyperplasia, an uncommon variant of benign prostatic hyperplasia which does not carry any malignant potential. Awareness about this entity is essential to avoid misdiagnosis which can potentially lead to a wrong clinical management.