Ciprofloxacin is a commonly used flouroquinolone antibiotic. We report a case of serum sickness like drug reaction due to ciprofloxacin. Serum sickness like reaction is a cutaneous adverse drug reaction to various drugs. It presents as fever, cutaneous rash and arthralgia. Common drugs implicated in causing serum sickness like drug reaction include penicillins, cephalosporins and tetracyclines. We report a case of serum sickness like reaction due to ciprofloxacin in a 13 year old boy, who was prescribed oral ciprofloxacin by a local practioner for furunculosis.