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Journal of Case Reports
Syndrome of Inappropriate Anti-diuretic Hormone Secretion and Pregabalin – a Critical Alert on a Potentially Reversible Side-effect

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Sudhagar Mookkappan, Aneesh Basheer, Nayyar Iqbal
From the Department of General Medicine, Pondicherry Institute of Medical Sciences,
Pondicherry-605014, India.
Corresponding Author:
Dr. Sudhagar Mookkappan
Email: drsudhagar_ms@yahoo.in
Received: 18-AUG-2014 Accepted: 24-SEP-2014 Published Online: 25-OCT-2014
DOI: http://dx.doi.org/10.17659/01.2014.0103
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the commonest cause of euvolemic hyponatremia. Several drugs are known to cause this syndrome. Pregabalin, a drug now used widely for a number of neurologic disorders, may cause hyponatremia secondary to salt wasting nephropathy. However, SIADH induced by pregabalin has been reported very infrequently in the literature. We report a case of hyponatremia in a patient started on pregabalin recently, who fulfilled criteria for SIADH and rapidly reversed on discontinuation of the drug. Awareness of this complication will help the clinician to diagnose and treat new onset hyponatremia in patients started on pregabalin.
Keywords : Hyponatremia, Nervous System Diseases, Inappropriate ADH Syndrome, Vasopressins, Humans.
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