Hashimoto’s encephalopathy is an uncommon neurological disorder of unknown etiology, found in association with thyroid autoimmunity. This is a case of a 60 year old Indian lady who had an episode of acute onset encephalopathy. High levels of antithyroid antibodies were found in her serologic studies. Her cerebrospinal fluid analysis was near normal. Magnetic resonance imaging showed a lacunar infarct in pons and vasculitis. Her electroencephalographic studies were consistent with Hashimoto’s encephalopathy. Hashimoto’s encephalopathy is a poorly understood syndrome, which is often under recognized because of its heterogeneous neurological symptoms. Hence, it is important to have an insight regarding the clinical manifestations and treatment of this rather uncommon condition.