Calculous biliary disease represents one of the most common causes of hepatobiliary illnesses requiring hospitalization in middle aged individuals. Presence of stones in the gallbladder (GB) may cause chronic fibrosis and loss of function of gallbladder, condition called as chronic cholecystitis. Laparoscopic cholecystectomy is the gold standard treatment for symptomatic gallstones presently. We present a case of micro-gallbladder in a middle aged female where the gallbladder was so much shrunken and embedded in the liver bed that laparoscopic cholecystectomy could not be done due to technical difficulty, so gall bladder was removed by open method. Patients behaved well in postoperative period.