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Abstract
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Hurthle cell carcinoma of thyroid, a variant of follicular carcinoma is a relatively rare type of differentiated thyroid cancer. Paraneoplastic neurological syndromes (PNS) are rare, affecting less than 1% of cancer patients overall [1]. Our patient, a 67 years old lady presented with progressive lower limb weakness of few months duration. She was aware of an enlarging thyroid swelling and recently experienced a few thyrotoxic symptoms. She was overtly thyrotoxic and had a large asymmetric goiter and severe weakness of proximal muscles in lower limbs. Clinical and investigation results were consistent with the diagnosis of diffuse toxic goiter and mononeuritis multiplex. She underwent thyroidectomy and the histopathological examination confirmed coexisting Hurthle cell carcinoma. We present her as a case of diffuse toxic goiter with coexisting thyroid cancer, Hurthle cell carcinoma with distant metastasis, and limb weakness due to mononeuritis multiplex, possibly a paraneoplastic neurologic syndrome. |
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Keywords :
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Adenocarcinoma, Goiter, Mononeuropathies, Paraneoplastic Syndromes, Thyroid Neoplasms.
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