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Journal of Case Reports
Leucovorin/5-Fluorouracil Induced Hypocalcemia

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Raya A Almazrouei, Fatima M Alkaabi
Division of Diabetes and Endocrinology, Department of Internal Medicine, Tawam Hospital - Al Ain, United Arab Emirates.
Corresponding Author:
Dr. Raya A Almazrouei
Email: rmazrooei@seha.ae
Received: 24-MAR-2016 Accepted: 25-JUN-2016 Published Online: 10-JUL-2016
DOI: http://dx.doi.org/10.17659/01.2016.0076
Abstract
Hypocalcemia is a relatively common metabolic abnormality that is observed in hospitalized patients. Drug related hypocalcemia is usually missed in such patients as a consequence of multiple contributing factors that lead to low calcium levels. We report a case of hypocalcemia  in a 34 years old lady with metastatic gastric adenocarcinoma after initiation of palliative chemotherapy with combination of leucovorin and 5-fluorouracil. The mechanism beyond this side effect is explored in this case. Effective clinical management can be handled through awareness of this adverse effect induced by certain chemotherapeutic agents on serum calcium level. 
Keywords : Adenocarcinoma, Calcium, Dihydroxycholecalciferols, Hypocalcemia, Leucovorin.
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