Sclerosing angiomatoid nodular transformation (SANT) is a benign non-neoplastic vascular splenic lesion consisting of multiple angiomatoid nodules surrounded by dense fibrous tissue. As its characteristic imaging features, low signal intensity on T2-weighted MR imaging and characteristic enhancement patterns on dynamic contrast-enhanced CT and MRI have been reported. Meanwhile, only a few cases that had calcifications within SANT on imaging have been reported. Herein we report a case of SANT that showed scattered punctate foci of calcification on imaging, and suggest the mechanism and significance of calcification in SANT in association with image diagnosis of this disease.