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Journal of Case Reports
Isolated Case of Hemimegelencephaly Presenting as Neonatal Seizure

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Anice Joy, Nisha Ayyappanparambil Ravindran, Grace Thomas,  Ravi Tharayil Velunny
Department of Pediatrics and Neonatology, Ernakulam Medical Centre, Kochi, Kerala, India.
Corresponding Author:
Dr. Anice Joy
Email: dr_anicejoy@yahoo.com
Received: 08-MAR-2016 Accepted: 19-AUG-2016 Published Online: 15-OCT-2016
DOI: http://dx.doi.org/10.17659/01.2016.0118
Abstract
Hemimegelencephaly is a rare congenital disorder of developing neurons of the brain believed to be due to hamartomatous proliferation or overgrowth of one cerebral hemisphere. We present a case of a neonate born out of full term normal delivery presenting as generalized tonic clonic seizure. Physical examination was normal and routine metabolic workup as unrevealing. MRI of brain showed hypertrophy of right cerebral hemisphere with dilatation of lateral ventricle with normal contralateral cerebral hemisphere which clinched the diagnosis of right hemimegelencephaly. Etiological evaluation for underlying syndromic cause was also futile. He was started on anti-epileptics and there was no further episode of seizure during hospitalization and follow up. 
Keywords : Anticonvulsants, Brain, Lateral Ventricles, Neurons, Seizures.
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