A 45 years male presented with C5-C6 flexion-distraction injury with quadriplegia (ASIA-A), and after reduction, was operated for anterior stabilization and fusion. Twenty two hours after uneventful surgery, patient sustained hypoxic-ischemic-encephalopathy in an episode of seizure. Following this, he had multiple episodes of hypothermia (92°F) with bradycardia and desaturation, responding well to rewarming measures. Episodes were infrequent initially, subsequently became frequent, with basal readjustment of core temperature to 94°F, following which bradycardia and desaturation settled. Such instance of basal readjustment of core temperature in a cervical injured patient with ischemic brain injury has never been reported.