About the Journal | Editorial Board | Instructions to Contributors | Submission & Review | Advertise with Us | Subscribe to E- Alerts
Sitemap | Feedback
Advanced search
Journal of Case Reports
ROS1 Gene Rearrangement Positive Non-small cell Lung Cancer
Dinesh Chandra Doval1,2, Rupal Sinha2, Moushumi Suryavanshi3, Kumardeep Dutta Choudhury1, Ajay Sharma1, PS Choudhury4, Anurag Mehta3
Departments of Medical Oncology1, Research2, Laboratory Services3, Nuclear Medicine4; Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India.
Corresponding Author:
Dr. Dinesh Chandra Doval
Email: dcdoval@gmail.com
Received: 20-AUG-2016 Accepted: 06-DEC-2016 Published Online: 10-JAN-2017
DOI: http://dx.doi.org/10.17659/01.2017.0004
Abstract
Background: Cancer treatment has witnessed a paradigm shift due to identification of driver mutations at the genetic level with cognate targeted therapies to negate the same. Development of acquired resistance is however, inevitable. Case Report: We present the case of a non-small cell lung (NSCLC) cancer patient with ROS1 gene rearrangement who developed acquired resistance to crizotinib. Conclusion: This case brings into light the rare NSCLC patient with ROS1 gene rearrangement in Indian population.
Keywords : Crizotinib, Gene Rearrangement, Mutation, Non-Small-Cell Lung Carcinoma.
Article Options
FULL TEXT
ABSTRACT
PDF
PRINTER FRIENDLY VERSION
Search PubMed for
Search Google Scholar for
Article Statistics
Bookmark and Share