Background: Spontaneous regression of cancer is rarely seen in brain tumors. We report a spontaneous regression of a suspected temporal lobe glioblastoma multiforme (GBM) and its re-appearance at a different site within a period of six months. Case Report: A 45 year old male presented with complaint of headache since four months and nausea, vomiting and blurring of vision since last one month. Radiological imaging was suggestive of a right temporal lobe lesion most probably high grade glioma. The patient did not undergo surgery due to personal reasons. He presented again, six months later, with exaggeration of previous symptoms. Fresh radiological imaging revealed a right parietal lobe lesion with no lesion in the previous site. Patient underwent surgery and histopathological examination was suggestive of grade IV glioblastoma. Conclusion: Spontaneous regression of a glioblastoma, to our knowledge, has never been reported in the world literature. This case report highlights the need to look for newer aspects of tumor biology in GBM.