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Journal of Case Reports
Spontaneous Regression of a Suspected Temporal lobe Glioblastoma Multiforme and its Re-appearance at a Different Site

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Charandeep Singh Gandhoke1, Mohammad T Ansari1, Simran K Syal2, Daljit Singh1, Ravindra Kumar Saran3
Departments of 1Neurosurgery and 3Pathology, Maulana Azad Medical College and G.B. Pant Institute of Post Graduate Medical Education and Research (GIPMER), New Delhi; 2Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India.
Corresponding Author:
Dr. Charandeep Singh Gandhoke 
Email: charandeepsingh2008@gmail.com
Received: 20-MAR-2017 Accepted: 22-MAY-2017 Published Online: 15-JUN-2017
DOI: http://dx.doi.org/10.17659/01.2017.0059
Abstract
Background: Spontaneous regression of cancer is rarely seen in brain tumors. We report a spontaneous regression of a suspected temporal lobe glioblastoma multiforme (GBM) and its re-appearance at a different site within a period of six months. Case Report: A 45 year old male presented with complaint of headache since four months and nausea, vomiting and blurring of vision since last one month. Radiological imaging was suggestive of a right temporal lobe lesion most probably high grade glioma. The patient did not undergo surgery due to personal reasons. He presented again, six months later, with exaggeration of previous symptoms. Fresh radiological imaging revealed a right parietal lobe lesion with no lesion in the previous site. Patient underwent surgery and histopathological examination was suggestive of grade IV glioblastoma. Conclusion: Spontaneous regression of a glioblastoma, to our knowledge, has never been reported in the world literature. This case report highlights the need to look for newer aspects of tumor biology in GBM.
Keywords : Brain Neoplasms, Glioblastoma, Headache, Parietal Lobe, Temporal Lobe.
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