Background: Intra-spinal oxidized cellulose-induced post-operative paraplegia has been a rare but devastating complication and has been variedly reported. This is one of the common hemostatic agent used and invariably left in-situ. However, oxidized cellulose is associated with the peculiar chemical property to swell and cause pocket-compression, especially in confined areas, which may recover but can also cause an everlasting complete/partial neurological deficit. Case Report: Our patient, a 68 year old female operated for a D3-D5 level meningioma developed post-surgical acute-onset paraplegia. An immediate post-operative MRI, urgent re-exploration and meticulous decompression resulted in complete neurological recovery at six months post-operatively. Conclusion: We, thus, present this unusual but well-documented oxidized cellulose related complication and make an attempt to highlight and suggest some basic teaching points.