Background: Mesenteric panniculitis is a rare, benign and chronic fibrosing inflammatory disease that affects the adipose tissue of the mesentery of the small intestine and colon. Sometimes mesenteric panniculitis may mimick non-Hodgkin lymphoma (NHL) or may be associated with it. Case Report: A 45 year old male presented to us with complain of abdominal lump and episodic abdominal pain. Surgical resection was done with provisional diagnosis of NHL. However, histo-pathology was suggestive of mesenteric panniculitis. Conclusion: This case was reported in view of the rarity of this entity and to give emphasis that biopsy is mandatory in such cases as sometimes mesenteric panniculitis may mimic NHL or may be associated with it.