Background: The posterior reversible encephalopathy syndrome (PRES) or reversible posterior leukoencephalopathy syndrome (RPLS) includes headache, visual disturbance, and seizure, altered mental status with or without focal neurological signs. Here, we present a 24 year old postpartum female with PRES in the setting of post-partum eclampsia with cortical blindness and seizure. Case Report: A 24 year old African American female presented with severe, constant, throbbing, bilateral occipital headache nine days after normal spontaneous vaginal delivery followed by blurred vision for two days.  It was complicated by generalized tonic-clonic witnessed seizure. Magnetic Resonance Imaging (brain) showed findings consistent with posterior reversible encephalopathy syndrome. The patient was successfully managed with intravenous labetolol and magnesium sulfate for eclampsia in intensive care unit. Conclusion: Focussed clinical approach, early detection of significant neuroimaging findings upon presentation, timely aggressive treatment and cessation of causal agents are crucial for satisfactory recovery and outcomes. This syndrome is overlooked by the physicians and usually radiologists are the saviors for timely diagnosis for PRES.