Background: Ventricular septal rupture (VSR) is a rare and lethal complication of acute myocardial infarction. Case Report: A 56 year old male following acute myocardial infarction (MI) was discovered to have ventricular septal (VS) rupture. Cardiac echocardiography (ECHO) confirmed the VS rupture. Conclusion: Usually MI is diagnosed by electrocardiography but in case of any physical finding we must do an cardiac ECHO. This case emphasizes the importance of echocardiography following an acute MI.