Background: Blocked feeding jejunostomy tube is a common problem for which medical attention is sought. The problem of feeding jejunostomy tube clogging is common due to errors in medication regimen and feeds given through tube. Case Report: We describe a 63 year old with superior mesenteric artery syndrome, whose laparoscopically created feeding jejunostomy tube was clogged due to accidental feeding of resonium through the tube. Subsequently, the patient underwent a novel method of fluoroscopic guided replacement of jejunostomy tube, carried out without local anesthesia or sedation. Conclusion: The best way to deal with tube unclogging is to prevent it. Clear hospital protocols regarding the proper care of feeding tubes including medication should be available and reinforced to the nurses caring for patients on jejunostomy tube.