Background: Deranged liver functions in patients with systemic lupus erythematosus (SLE) may be caused by drugs, viral hepatitis, fatty liver or lupus hepatitis; however SLE patient with autoimmune thyroiditis developing autoimmune hepatitis have rarely been described. Case Report: A 22 year old girl who had a background history of systemic lupus erythematosus and autoimmune thyroiditis presented to us with altered liver functions and right upper quadrant pain and was diagnosed to have autoimmune hepatitis. Conclusion: Autoimmune hepatitis is a rare in patients with SLE but polyautoimmunity is something we need to consider in patients who already have one existing autoimmune disease. Polyautoimmunity should be added in list of differential diagnosis when investigating patients with deranged liver functions if the clinical picture is suggestive.