Background: Intussusception is a rare cause of bowel obstruction in adults. Even if intussusception in children is almost always a benign condition due to a congenital laxity of mesentery; in young adults this condition can be often a consequence of a malignancy like an appendiceal neuroendocrine tumor or lymphoma. Case Report: We present a case of bowel intussusception in a 16 years old male admitted to our Emergency Department for recurrent abdominal pain, who underwent a right hemicolectomy after CT scan and colonoscopy. Pathological examination showed a large B-cell lymphoma of the appendiceal foramen leading to a colo-colonic intussusception with bowel obstruction. Conclusion: Intussusception in young adults must be investigated further as it may be symptom of a malignancy.