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Journal of Case Reports
Nitrous Oxide Induced Subacute Combined Degeneration
Huimin Zhao, Zhongmin We, Yingying Xu
Department of Neurology, The Second Affiliate Hospital of Soochow University, Suzhou, China.
Corresponding Author:
Dr. Yingying Xu
Email: xyy3564@163.com
Received: 11-FEB-2019 Accepted: 21-AUG-2019 Published Online: 30-SEP-2019
DOI: http://dx.doi.org/10.17659/01.2019.0053
Background: Nitrous oxide (N2O), due to its euphoriant properties is often abused for recreational purpose. Case Report: A 38-year-old male who admitted to inhaling recreational nitrous oxide more than five months, presented with a progressive symmetrical tingling sensations and weakness of limbs. Serum vitamin B12 was lower than normal. Magnetic resonance imaging (MRI) of the spine demonstrated hyper-intensity of the posterior cord extending from C1-C5. Nerve conduction velocity test showed slowed motor conduction velocities and delayed or absent F-waves consistent with demyelinating neuropathy. The patient was managed with B12 supplement and his nerve function basically returned to normal after three months. Conclusion: This is a rare case of subacute combing degeneration caused by excessive inhalation of nitrous oxide.
Keywords : Demyelinating Diseases, Magnetic Resonance Imaging, Neural Conduction, Nitrous Oxide, Vitamin B12.
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