Background: Wernicke’s encephalopathy (WE) is a rare condition resulting from chronic malnutrition. The commonest cause of WE is chronic alcoholism. Hyperemesis in pregnancy is another overlooked condition that can result in chronic malnutrition and can precipitate WE. WE in pregnancy leads to poor outcomes both for the mother and the baby. It is a rare condition and needs a high degree of suspicion for diagnosis. Case Report: A 27 years old pregnant lady presented to our hospital in altered sensorium. After excluding the common causes of encephalopathy in pregnancy, WE was considered due to a history of hyperemesis. The MRI of brain supported the diagnosis. The woman was started on thiamine and had a gradual improvement in her general condition. She went on to successfully complete the pregnancy and delivered a healthy baby. Conclusion: Early recognition of this condition and prompt thiamine administration was the key to successful outcome.