Background: Simple bone cyst (SBC) is a rare benign tumor-like lesion and most frequently occurs in children and adolescents. There is still no official consensus to treat them. A report stated that decompression and percutaneous steroid injections (PSI) into the cyst yielded 96% positive results. Case Series: We identified all patients who were treated by decompression and PSI during 2013 and 2020. Sixteen cases reported in this serial case consists of 13 males and 3 females. The average age of these subjects is 8.5 years. Musculoskeletal Tumor Society (MSTS) functional score in 15 cases (94%) showed very good results, while 1 (6%) case showed fair result after 3rd injection of steroid. Decompression and percutaneous steroid injection therapy for SBC yielded good outcome. Conclusion: Follow-up after procedure of our patients shows very good functional outcome. Therefore, we recommend this procedure as treatment for SBC cases.