Background: Spontaneous tracheal rupture is one of the rare life-threatening conditions. Tracheal lacerations are generally secondary to cervical or chest trauma or occurring as a complication of endotracheal intubation. Spontaneous trachea-bronchial tree injury (TBI) are potential killers if not diagnosed early and treated adequately. Case Report: We hereby report two case reports of spontaneous TBI, one secondary to a lower respiratory tract infection (LRTI) and the other secondary to COPD with long term steroid use. There are only less than 5 case reports till date, published on spontaneous TBI. Conclusion: Spontaneous TBI are life-threatening, under reported, rare and difficult to diagnose and has a high mortality rate.