Villous tumours of digestive tract are rare and pre malignant lesions. Their discovery is, usually, fortuitous during an endoscopic examination. The removal of villous tumours must be complete, because of their recurrence and degeneration potential. Large villous tumors are still a limitation for endoscopic removal and need a surgical management. High morbidity and mortality rate and functional disorders of radical surgery have led to an increasing interest in many other procedures which can expose to recurrence risk especially in rectal localization. We review the literature and report our experience in managing two cases of large villous tumours in two different localizations.