Rowell’s syndrome is a rare manifestation of systemic lupus erythematosus characterized by skin lesions resembling erythema multiforme in the background of antinuclear antibody (ANA), anti-La (SS-B)/anti-Ro (SS-A) antibodies and rheumatoid factor (RF) positivity. Here we present the case of a 20 year old Asian girl, known case of SLE for 1 year, presenting with itchy erythematous targetoid lesions and dyspnoea. ANA (with speckled pattern), anti-ds DNA, RF, anti-La and anti-Ro antibodies were positive. Skin biopsy revealed the histological picture of erythema multiforme. Her dyspnoea was attributed to the presence of massive pericardial effusion. Case reports of Rowell’s syndrome are very rare in literature and some of the reported cases do not conform to the classical description. This case is close to the classical ‘Rowell’s Syndrome’, which makes it reportable.