Background: Bleomycin, glycopeptide antibiotic, is a key chemotherapeutic agent with fatal pulmonary toxicity. Pulmonary adverse events of bleomycin vary from pneumonia to fatal interstitial fibrosis. Case Report: We hereby report a rare case of bleomycin induced acute respiratory distress syndrome in a patient with dysgerminoma ovary. Conclusion: In presence of risk factors, physicians administrating bleomycin should be aware of potential lung toxicity.