Background: Elizabethkingia meningoseptica infections are not common but are clinically important because the organism is naturally resistant to multiple antibiotics. A prompt diagnosis is important so as to give appropriate antibiotic treatment. Case Report: We report a case of central line associated Elizabethkingia meningoseptica infection in a patient who was admitted with recurrent oligodendroglioma and underwent right frontal craniotomy and surgical decompression of tumor. Conclusion:  Elizabethkingia meningoseptica infection should always be considered in the etiological diagnosis of septicemia who do not respond to empirical therapy as this results in an inappropriate choice of antimicrobial therapy, which may lead to increased morbidity and mortality of patients infected by this pathogen.