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Journal of Case Reports
Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug
Madhuri Rudraraju1, Varun Parvathagiri1, Manish Dugar2
1Pharm.D Interns, Sri Venkateshwara College of Pharmacy, Affiliated to Osmania University, Hyderabad; 2Consultant Rheumatologist, Apollo Hospitals, Hyderabad, India.
Corresponding Author:
Dr. Madhuri Rudraraju
Email: madhu.rudraraju5@gmail.com 
Received: 02-JAN-2017 Accepted: 07-MAR-2017 Published Online: 10-APR-2017
DOI: http://dx.doi.org/10.17659/01.2017.0037
Abstract
Background: Interstitial nephritis, complication of anti-tubercular therapy has been most commonly reported due to rifampin therapy. The mechanism of rifampin-induced acute kidney injury is either a type II or type III hypersensitivity reaction induced by rifampin antigens in which anti-rifampin antibodies form immune complexes that are deposited in renal vessels, the glomerular endothelium, and the interstitial area. Case Report: We describe a case of 57-year-old man with rheumatoid arthritis who developed acute kidney injury with prominent tubular dysfunction after starting anti-tubercular therapy containing rifampin. Conclusion: Acute tubulo-interstitial nephritis should be included in the differential diagnosis in acute kidney injury and renal tubular damage following rifampin initiation.
Keywords : Acute Kidney Injury, Acute Tubulointerstitial Nephritis, Kidney Tubules, Nephritis, Rifampin.
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