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Journal of Case Reports
A Novel Cytogenetic Variant Translocation in Acute Myeloid Leukemia
Monika V Patel1, Salil N Vaniawala2, Pankaj K Gadhia2
1,2JJTU University, Rajasthan, India; 2Molecular Cytogenetic Unit, S.N. Gene Laboratory and Research Centre, Surat, India.
Corresponding Author:
Dr. Pankaj K. Gadhia
Email: pankajkgadhia@gmail.com
Received: 12-JUN-2017 Accepted: 10-JUL-2017 Published Online: 30-JUL-2017
DOI: http://dx.doi.org/10.17659/01.2017.0072
Abstract
Background: Acute myeloid leukemia (AML) is a heterogeneous group of malignant neoplasm of hematopoietic disorders characterized by an abnormal proliferation of myeloid precursors. Variant forms of classic translocation t(8;21) are uncommon, and either third or fourth chromosomes accounts for approximately 3-4% in acute myeloid leukemia. Case Report: We report a rare case of a 16-year old male having t(8;19;21)(q22;q13;q22) associated with  loss of sex chromosome. To the best of our knowledge, only few cases are described with variants of t(8;21) in AML and we first time report the involvement of 19q13 breakpoint region in AML. Conclusion: Translocation t(8;19;21)(q22;q13;q22) is a novel, rare but recurrent variant translocation of t(8;21). Due to the rarity of this translocation future accumulation of similar cases needed to evaluate clinical as well as prognostic and biological features.
Keywords : Chromosomes, Cytogenetics, Karyotyping, Neoplasms, Sex Chromosome, Translocation.
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