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Journal of Case Reports
Factor XIII Deficiency Presenting with Intra-cerebral Hemorrhage
Lekshmi Sudev, Nittin Henry, N.I Kurian, Susheela J Innah
Department of Immunohematology & Blood Transfusion, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, India.
Corresponding Author:
Dr. Lekshmi Sudev
Email: dr.lekshmisudev@gmail.com
Received: 02-APR-2017 Accepted: 30-JUL-2017 Published Online: 20-SEP-2017
DOI: http://dx.doi.org/10.17659/01.2017.0085
Abstract
Background: Factor XIII deficiency is a rare disorder which generally presents with life threatening bleeds. Case Report: A 44 year old male presented with spontaneous left sided weakness and frontal headache for 3 days. The patient had recurrent episodes of umbilical stump bleeding and recurrent muco-cutaneous bleeds. The patient was transfused with blood components in the past. The coagulation profile showed normal prothrombin time, activated partial thromboplastin time and platelet count. Patient showed decreased clot stability with 5M urea solubility test. CT brain showed right temporal large hemorrhagic contusion. A parieto-occipital craniotomy and evacuation was done after transfusion of cryoprecipitate. Post-operative period was uneventful. Conclusion: The investigation by clot lysis test in the presence of a normal coagulation profile on a case with high index of suspicion is recommended. The patient was successfully managed with cryoprecipitate transfusion and supportive care.
Keywords : Blood Coagulation Tests, Brain, Craniotomy. Factor XIII Deficiency, Urea Solubility.
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