Background: Neonatal meningitis remains a life threatening invasive infection that needs a comprehensive approach. Early diagnosis and institution of appropriate empiric antibiotic therapy will be life-saving and decrease complications. Case Report: We report the case of a fifteen day-old boy presenting for sepsis evaluation with one day history of high grade fever, irritability and poor feeding. Sepsis work up revealed meningitis secondary to Moraxella catarrhalis. Conclusion: Moraxella catarrhalis is a gram negative bacteria that is rarely reported in late onset neonatal sepsis, and we will review the latest literature on neonatal meningitis secondary to M. catarrhalis.