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Journal of Case Reports
Treatment of Type I Diabetes using Autologous Adipose Derived Mesenchymal Stem Cells Translated to Insulin Secreting Islet like Cell Aggregates

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Jaymesh M  Thadani, Anant Marathe, Shivani Vakodikar,  Prashant Kshatriya,  Dhwani Modi, Rajni Vyas, Bhaskar Vyas
Total Potential Cells (P) Ltd, 1st floor Parimal Majumdar Wada, Pratap road, Raopura. Vadodara-390001. Gujarat, India.
Corresponding Author:
Dr. Anant Marathe
Email: dranantmarathe@hotmail.com
Received: 08-MAR-2017 Accepted: 02-JUN-2017 Published Online: 05-JUL-2017
DOI: http://dx.doi.org/10.17659/01.2017.0064
Abstract
Background: A number of papers describe different stem cell lines as the presenting feature to treat diabetes. Case Report: We report a 21 year old female with type 1 diabetes mellitus who was treated with islet like cell aggregates (ICAs) translated from autologous adipose derived mesenchymal stem cells (ADMSCs). Half of the total count of autologous adipose-derived stromal vascular fraction (AD-SVF) was injected intramuscularly. The other half was purified to ADMSCs and translated to ICAs and injected by intra-hepatic route. The patient showed remarkable decrease in her insulin requirement. No side effects were noted related to the treatment. Conclusion: The case study suggests AD-SVF and ADMSCs translated to ICAs is effective alternative strategy for the treatment of juvenile diabetes.
Keywords : Adioposity, Cell Line, Diabetes Mellitus, Mesenchymal Stomal Cells, Islets of Langerhans.
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