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Journal of Case Reports
Primary Central Nervous System B Cell Lymphoma, Unclassifiable, in an Immunocompetent Young Male
Meera PP, Bhulaxmi P1
Departments of Pathology and 1Laboratory Medicine, Yashoda Hospital, Somajiguda, Hyderabad, Telangana-500082, India. 
Corresponding Author:
Dr. Meera PP 
Email: meerapoonacha@gmail.com
Received: 28-JUL-2017 Accepted: 01-OCT-2017 Published Online: 20-OCT-2017
DOI: http://dx.doi.org/10.17659/01.2017.0093
Abstract
Background: Primary CNS B cell lymphoma, unclassifiable with features intermediate between diffuse large B cell lymphoma and Burkitt’s lymphoma (DLBCL/BL) in an immuno-competent young boy is a rare entity. Case Report: A 14 year old boy presented with headache and vomiting. CT brain showed well-defined mildly enhancing hyper-dense lesion in left intra-ventricular region with seeding in the temporal lobe and the supra-sellar region suggesting a neoplastic condition. Squash cyotology of specimen after tumor decompression suggested high grade non-Hodgkin’s lymphoma. Tissue paraffin sections showed tumor cells diffusely positive for CD20, BCl6, and BCl2, focally positive for CD10 and negative for Tdt on immunohistochemistry. Mib1 index was nearly 100%. In view of high Mib 1 index and strong Bcl2 positivity and in the absence of disease elsewhere in the body on PET CT, a diagnosis of primary CNS B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL was given. Conclusion: Primary CNS B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL can also occur in young immuno-competent patients. Though rare, these lymphomas are also known to occur in the central nervous system.
Keywords : Brain, Burkitt lymphoma, Diffuse Large B cell Lymphoma, Headache, Immunohistochemistry, Vomiting.
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